Synergism between NF-kappa B inhibitor, celastrol, and XIAP inhibitor, embelin, in an acute myeloid leukemia cell line, HL-60
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چکیده
منابع مشابه
Inhibition of NF-kappaB in fusogenic membrane glycoprotein causing HL-60 cell death: implications for acute myeloid leukemia.
Viral fusogenic membrane glycoproteins (FMGs) are new therapeutic genes for the control of tumor growth, the cellular mechanisms mediating cell death is non-apoptotic. However, the precise molecular mechanism remains to be elucidated. Here, we showed overexpression of HSP70 in HL-60 cells mediated by Gibbon Ape leukemia virus hyperfusogenic envelope protein (GALV-FMG) inhibited the nuclear tran...
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CXCL-12 and its receptor CXCR4 participate in breast cancer and melanoma cell metastasis to bone and lymphoid nodes. CD44, as a receptor for hyaluronic acid, is involved in lymphocyte recirculation, homing, adhesion and migration. But the role of CD44 in CXCL-12 induced leukemia cell migration still remains unclear. The present study showed that CXCL-12 stimulation induced the rapid internaliza...
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In this study we examine the effects of amino acid deprivation on the growth and differentiation of the human HL-60 myeloid leukemia cell line. The HL-60 cell line was chosen for study because of its ability to differentiate along either a granulocytic or monocytic pathway under appropriate culture conditions. Differentiation was determined by changes in cell morphology, nonspecific esterase (N...
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I have read the very interesting and informative article of Hoover et al,1 which may open new avenues in treating imatinib-refractory and imatinib-sensitive chronic myeloid leukemia (CML). However, when testing the synergic potential of STI farnesyl transferase inhibitor (FTI) combination on the STI571-sensitive Baf BCR-ABL-s cell line, a deficient statistical proof is shown. In their Figure 2A...
متن کاملCharacterization of the continuous, differentiating myeloid cell line (HL-60) from a patient with acute promyelocytic leukemia.
In a prelminary communication, we described the establishment of a continuous human myeloid cell line (HL-60). Here we report the detailed properties of this cell line and document its derivation from the peripheral blood leukocytes of a patient with acute promyelocytic leukemia. As characterized by light and electron microscopy, the predominant cell type in both the fresh and cultured sources ...
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ژورنال
عنوان ژورنال: Journal of Cancer Research and Therapeutics
سال: 2016
ISSN: 0973-1482
DOI: 10.4103/0973-1482.150407